摘要
目的 :观察盐酸苯环壬酯片预防装甲车辆乘载员晕动病的疗效与不良反应。方法 :采用随机双盲交叉对照的方法 ,试验分盐酸苯环壬酯片 (n =31)、茶苯海明片 (n =33)和安慰剂 (n =31) 3组 ,口服剂量分别为 2 ,5 0和 10 0mg。 结果 :盐酸苯环壬酯片组总有效率 77.42 % ,显效率 48.38% ,与安慰剂相比有极显著性差异 (P <0 .0 1) ,与茶苯海明片组相比无统计学差异。盐酸苯环壬酯片组嗜睡发生率低 ,与其他 2组相比差异有显著性 (P <0 .0 5 )。结论 :盐酸苯环壬酯片是预防晕动病的安全有效药物。
Objective:To observe the efficacy of phencynonate hydrochloride tablets in prevention of motion sickness.Methods:The randomized,double blind,controlled crossover study was conducted in tank crews.They were divided to receive phencynonate hydrochloride tablets 2mg,or dimenhydrinate 50mg,or placebo 100mg.Results:The total effective rate and significant effective rate for phencynonate hydrochloride tablets group were 77.42% and 48.38% respectively.There was significant difference in efficacy between active and placebo groups (P<0.01) but no significant difference in comparison with control group.The sedative effect of phencynonate hydrochloride tablets was less pronounced in comparison with dimenhydrinate.Conclusion:Phencynonate hydrochloride tablets is a safe and effective agent for prevention of motion sickness.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2001年第6期453-454,共2页
Chinese Journal of New Drugs
