摘要
目的探讨ｃｙｃｌｉｎＤ１、ｃｙｃｌｉｎＥ和ｐ２７蛋白在胃癌中的表达及其意义。方法用免疫组化法检测６０例胃癌组织中 ｃｙｃｌｉｎ Ｄ１、ｃｙｃｌｉｎ Ｅ和 ｐ２７蛋白的表达。结果胃癌组织中 ｃｙｃｌｉｎ Ｄ１、ｃｙｃｌｉｎ Ｅ和 ｐ２７蛋白表达阳性率分别为４１．７％（２５／６０）、３８．３％（２３／６０）和 ３６．７％（２２／６０）；ｃｙｃｌｉｎ Ｄ１在胃癌中的表达与肿瘤 Ｌａｕｒｅｎ分型相关，ｃｙｃｌｉｎ Ｅ在胃癌中的表达与肿瘤分化程度、浸润深度及肿瘤分期相关，而ｐ２７蛋白的表达与肿瘤浸润深度、淋巴结转移和肿瘤分期相关。另外，ｃｙｃｌｉｎ Ｅ和 ｐ２７蛋白在胃癌中的表达呈现显著负相关。结论检测胃癌组织中ｃｙｃｌｉｎ Ｄ１、ｃｙｃｌｉｎ Ｅ和 ｐ２７蛋白的表达有助于判断肿瘤的进展程度。
Objective To study the expression and its significance of cyclin D1,cyclin E and p27 protein in gastric carcinoma. Methods The expression of cyclin D1,cyclin E and p27 protein in 60 cases of gastric carcinoma were detected by immunostaining method. Results The positive rates of cyclin D1, cyclin E and p27 protein expression in gastric carcinoma were 41. 7% (25/60), 38. 3 % (23/60) and 36. 7 % (22/60), respectively. The expression of cyclin D1 was significantly correlated with Lauren type of tumor, the expression of cyclin E was significantly correlated with tumor differentiation, infiltration and stage, while the expression of P27 protein was significantly correlated with tumor infiltration,lymph nodes metastasis and stage. Further more, the expression of cyclin E was inversely correlated with the expression of p27. Conclusion Detection of cyclin D1,cyclin E and p27 expression in gastric carcinoma may be helpful in determining tumor progression.
出处
《中国普外基础与临床杂志》
CAS
2001年第3期148-150,共3页
Chinese Journal of Bases and Clinics In General Surgery
基金
江苏省科委科研项目(BS99317)
