摘要
目的探讨血中总胆汁酸在原发性高血压发病中的作用。方法酶法检测 30例健康人、2 1例继发性高血压及 76例原发性高血压患者血清总胆汁酸并进行比较。结果继发性高血压患者血清总胆汁酸值和对照组比较无差异 (P>0 .0 5 ) ;原发性高血压患者血清总胆汁酸值较继发性高血压及对照组均明显升高 (P<0 .0 1)。其中 级高血压患者总胆汁酸值大于 级患者 (P<0 .0 5 )。但 级和 级高血压患者及 级和 级高血压患者血总胆汁酸值相比较无显著差异 (P均 >0 .0 5 )。
Objective To investigate the role of total bile acid (TBA) in pathogenesis of essential hypertension.Methods The concentration of serum TBA was measured by enzymatic method in 127 cases including 30 healthy controls,21 secondary hypertensive patients and 76 essential hypertensive patients.Results There was a significant increase of TBA in essential hypertensive group compared with that of control group and secondary hypertension (P<0.01).No significant difference was found in TBA levels between secondary hypertensive and control group (P> 0.05) .In essential hypertensive group,the levels of TBA in grade 3 hypertension were higher than that of grade 1 hypertension (P<0.05).No significant difference was found in TBA levels between grade 3 and grade 2 hypertension or grade 2 and grade 1 hypertension (P>0.05).Conclusion The abnormal increasing of TBA may play a role in pathogenesis of essential hypertension.
出处
《中国综合临床》
北大核心
2001年第8期577-578,共2页
Clinical Medicine of China
