摘要
目的 :建立复方氨酚烷胺胶囊溶出度的测定方法。方法 :转篮法 ,采用ODS柱 ,流动相为V(甲醇 )∶V (0 .0 5mol/L磷酸二氢钾 ) =10 0∶40 0 ,检测波长为 2 5 4nm。结果 :对乙酰氨基酚的线性范围为 0 .110 8～ 0 .775 6μg ,回收率为 10 0 .7% (RSD =0 5 0 % )。结论 :本方法结果准确 。
Objective:To establish a HPLC method for the determination of the dissolution of Compound Paracetamol and Amantadine Hydrochloride Capsules. Method: A basket stirring method was applied. ODS column was used ,with the mobile phase of 0.05 mol/L KH 2PO 4 methanol(40∶10) and detective wavelength of 254 nm. Results:The linear range of paracetamol was 0.1108～0 7756 μg.The average recovery ( n =5) was 100.7% ( RSD =0.50%). Conclusion:The method is accurate and suitable for the determination of the dissolution of Compound Paracetamoland Amantadine Hydrochloride Capsules.
出处
《广东药学院学报》
CAS
2001年第2期89-90,95,共3页
Academic Journal of Guangdong College of Pharmacy
关键词
复方氨酚烷胺胶囊
对乙酰氨基酸
溶出度
解热镇痛药
compound paracetamol and amantadine hydrochloride capsules
paracetamol
dissolution
