摘要
目的:探讨灯盏花素治疗慢性肾小球肾炎的疗效及其机制。方法:62例慢性肾小球肾炎患者被随机分为对照组30例,常规、对症治疗;治疗组32例,在此治疗的基础上,加用灯盏花素20mL入液静脉点滴。结果:治疗组的24h尿蛋白定量、血肌酐、血尿素氮、全血粘度、血浆粘度、纤维蛋白原与治疗前比较都有显著性的改善(P<0.05或P<0.01),与对照组比较有显著性差异(P<0.05或P<0.01),对照组只有血尿素氮有显著性的改善(P<0.05)。结论:灯盏花素可减少尿蛋白的排出,改善肾功能,降低血黏度,改善肾脏微循环;适用于治疗慢性肾小球肾炎。
Objective:To investigate the effect of treatment on chronic glomerulonephritis with breviscapine. Methods: Sixty-two cases of chronic glomerulonephritis were randomly divided into both control and treatment groups. The control group was composed of thirty cases. They were all treated in usual ways. Twenty millilitre of breviscapine were given in-dripping one time daily to patients of treatment group for four weeks in addition to usual ways. 24 hours urine protein quantity (24h UPQ), blood creainine kinetic (Scr), blood urea nierogen(BUN), fibrinogen(FI), serumlipid and blood viscosity were measured before and after treatment. Results .-After treatment, only BUN improved significantly(P<0. 05) in the control group . In the treatment group, 24h UPQ, Scr, BUN, FI, serumlipid and blood viscosity improved significantly (P<0.05,or P<0.01). There were significant differences between the two groups after treatment (P<0.05 or P<0. 01). Conclusion: Breviscapineis were used for chronic glomerulonephritis by decreasing urine protein excretion quantity, improving renal function, improving hemorrheology in renal microcirculation, and lowering blood lipid.
出处
《医学理论与实践》
2001年第6期487-489,共3页
The Journal of Medical Theory and Practice
关键词
灯盏花素
慢性肾小球肾炎
24h尿蛋白排出量
血肌酐
血粘度
治疗
Breviscaptine, Chronic glomerulonephritis, 24 hours urine protein quantity, Blood creainine kinetic, Blood viscosity
