摘要
目的 探讨糖尿病患者血清铜蓝蛋白浓度变化及其临床意义。方法 糖尿病患者31例 ,分为有、无微血管病变亚组 ,并以健康者20例作对照组。均用速率散射免疫比浊法测定血清铜蓝蛋白浓度 ,同步检测24小时尿微量白蛋白。结果 糖尿病患者血清铜蓝蛋白浓度 (0.48±0.12) g/L ,较对照组 (0.31±0.09) g/L ,显著增高 (p<0.05);有微血管病变亚组(0.47±0.12)g/L比无微血管病变亚组(0.42±0.09)g/L亦显著增高(p<0.05) ;且血清铜蓝蛋白浓度与24小时尿微量白蛋白排出量之间呈显著正相关关系。结论 糖尿病患者血清铜蓝蛋白浓度增高 ,有微血管病变者其浓度进一步增高 。
Objective To explore the change of serum ceruloplasmin in patients with diabetes mellitus (DM) and the significance of such a change. Methods 31 DM patients were divided into two sub-groups: with or without microangiopathy, 20 healthy individuals were taken as controls. The concentration of serum ceruloplasmin was measured by the rate immnuonephelometry method. Results There was a significant increase in serum ceruloplasmin of DM patients comparing to controls (p<0.05). Those with microangiopathy had higher serum ceruloplasmin than those without microangiopathy (p<0.05). There was positive correlation between serum ceruloplasmin and 24h urinary microalbumin excretion. Conclusion serum ceruloplasmin detection had certain value to judge the existence of microangiopathy in DM patients.
出处
《浙江临床医学》
2001年第8期545-546,共2页
Zhejiang Clinical Medical Journal
关键词
糖尿病
铜蓝蛋白
微血管病变
Diabetes mellitus Ceruloplasmin Microangiopathy
