摘要
目的 比较大肠癌肝转移不同治疗方法的疗效 ,探讨治疗原则。 方法 对 89例大肠癌肝转移患者进行回顾性分析。将患者按照不同的治疗方法分为 4组 ,根据随访资料和统计学分析 ,比较各组的治疗效果。 结果 根治性手术切除组的 1、3年生存率分别为 80 %和 30 % ,最长者生存6 2个月。静脉化疗组中位生存期为 7个月 ,皮下植入泵肝动脉化疗组和经皮穿刺肝动脉导管化疗组的治疗有效率可达到 31 0 %和 46 5 % ,但长期疗效受肿瘤血供等因素影响 ,患者中位生存期为 15个月 ,经Cox逐步回归多因素分析 ,肝动脉化疗与静脉化疗在生存期上差异无显著性意义 (P =0 13)。结论 对于大肠癌肝转移患者 ,根治性手术切除是效果最好的治疗方法 ,肝动脉化疗能否延长患者生存期仍需进一步探讨。
Objectives To compare the effect of different treatments of colorectal liver metastases and to discuss the principles for the treatments. Methods Eighty nine patients with colorectal liver metastases were analyzed. The patients were divided into 4 groups according to different treatments, and the effects of the treatments were followed up and analyzed statistically. Results Ten patients had undergone curative resection with a 1 ,3 year survival rate of 80% and 30% respectively. The longest survival period was 62 months. Twenty patients accepted introvenous chemotherapy, with a median survival period of 7 months only. Thirteen patients underwent hepatic artery infusion with implanted pump and 43 patients underwent transcatheter arterial chemoembolization. The response rate of the two groups was 31% and 46 5%; their median survival period was 15 months. Intrahepatic chemotherapy could gain a higher response than systemic therapy, but there was no significant difference in survival as shown by multivariate analysis. Conclusions Curative resection is the best therapy for colorectal liver metastases. Whether intrahepatic chemotherapy prolongs patients′ survival should be further studied.
出处
《中华外科杂志》
CAS
CSCD
北大核心
2001年第5期337-340,共4页
Chinese Journal of Surgery
关键词
肿瘤转移
肝转移
肝动脉
药物联合治疗
大肠癌
Colorectal neoplasms
Neoplasm metastasis
Liver
Hepatic artery
Drug therapy, combination
