摘要
目的 探讨有家族史与无家族史银屑病患者的发病年龄、病情程度、发病季节及发病诱因等的关系。方法 采用问卷调查形式对 2 2 0例有家族史和 5 47例无家族史银屑病患者以及 6 47名正常对照进行调查 ,用EPIinfo软件对资料进行分析。结果 ① 2 2 0例有家族史银屑病患者中 ,一级亲属和二级亲属的患病率分别为 16 .98%、2 .70 %。而对照的一级亲属和二级亲属的患病率分别为0 .5 9%、0 .19%。②有家族史银屑病患者中 ,女性平均年龄、平均发病年龄较男性早 ,统计学分析差异有显著性 (t=1.715 0 ,P <0 .0 5 )。有家族史男性发病年龄较无家族史男性要早 ,而女性患者中则差异无显著性 (t=0 .7392 ,P >0 .0 5 )。③发病诱因、病情程度及发病季节在有家族史和无家族史间无统计学意义 ,但环境因素无论对有家族史还是对无家族史银屑病患者 ,在统计学上差异均有显著性(χ2 =0 .2 3,P <0 .0 5 )。结论 除平均年龄、平均发病年龄在有家族史和无家族史银屑病患者中存在统计学上显著差异外 ,发病诱因、病情程度及发病季节等则无统计学意义。说明遗传因素在有家族史患者中起着重要作用 。
Objective To investigate psoriasis patients with family history and non-family history on their age and season of onset, disease severity and predisposing factors. Methods Two hundred and twenty psoriasis patients with family history and 547 psoriasis patients without, together with 647 normal controls have been investigated through questionnaires. EPI info 6.0 method was applied for data analysis.Results ①In 220 psoriasis patients with family histories, morbidity rates of the first and second degree relatives were 16.98 % and 2.7 % respectively. ②Both mean age and age of onset were younger in females than that in males with family histories ( t = 1.715 0 , P < 0.05 ). The mean age of onset was younger in males with family histories than those without. However, there was no significant difference found in females ( t = 0.739 2 , P > 0.05 ).The mean age of onset seemed to be younger in females with family histories than that without, but with no significant statistical difference.③There were no significant differences in the age and season of onset, disease severity, and predisposing factors between groups with family histories and without. However,environment factors seemed to influence not only psoriasis patients with family histories but also those without, which showed significant difference (χ 2= 0.23 , P < 0.05 ). Conclusions There was no significant difference in the following aspects as season of onset, disease severity and predisposing factors between the ones with family history and those without, except the age of onset and age of average. The results showed that genetic factor might play an important role in psoriasis patients with family history. It also demonstrated that psoriasis is a multifactor hereditary disease.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2001年第3期215-218,共4页
Chinese Journal of Epidemiology
基金
安徽省自然科学基金资助项目! (990 442 3 7)
