摘要
介绍新型血液净化吸附剂交联琼脂包嵌凹凸棒微囊 (CAA)的制备工艺及性质、杂质的清除。CAA利用国产药用凹凸棒为吸附剂 ,经琼脂包嵌交联微囊化 ,得到的珠状吸附材料能耐热压灭菌 ,室温下保存半年性能未见明显变化。通过动态分批搅拌、小柱灌流系统试验研究了材料对亚甲蓝等模型化合物与某些中毒性药物的吸附特性及吸附容量。初步结果表明 ,该材料保留了凹凸棒的吸附性能 ,其中对含 N阳离子型化合物亚甲蓝及吩噻嗪类药物有相当强的选择吸附性能。体外试验及扫描电镜观测证实 CAA有较好的血相容性。
The preparation and properties of a new adsorbent cross-linked agar beads entrapped attapulgite clay (CAA) are reported in detail. Medicinal attapulgite clay made in China was encapsulated with agar, shaped in organic solvent, and cross-linked by epichlorohydrin. The products withstood autoclaving at 121°C for half an hour with no breakage, and had a good selective adsorption ability for some model compounds and medicaments such as methylene blue and phenothiazine drugs. Preliminary investigations and SEM photographs indicate that the CAA as an adsorbent is relatively hemocompatible for hemoperfusion.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2001年第2期330-332,F003,共4页
Journal of Biomedical Engineering
