摘要
目的 研究原发性高血压病患者血压变异与心脏结构和功能的关系。方法 110例原发性高血压患者根据有无左心室肥厚被分为两组 ,比较两组血压负荷和血压变异的特征及对部分心脏结构和功能指标的影响。结果 两组患者高血压年限差异无显著性 ,但左室重量 (LVM )、左室重量指数 (LVMI)、室间隔厚度 (IVS)、左室后壁厚度 (LVPW)和平均室壁厚度 (RWT)等均有显著不同。2 4h收缩压变异 (2 4hABPVs)、白昼收缩压变异 (dABPVs)、夜间收缩压下降率 (nSBPrr)、2 4h平均动脉压变异 (2 4hABPVm)、白昼平均动脉压变异 (dABPVm)、高血压性血管超负荷指数 (HINVOI)两组差异均有显著性。结论 ①高血压病在早期已有心脏舒张功能的损害 ;②高血压性左室肥厚不但与血管超负荷有关 ,并且与血压变异性有关 ;③因高血压知晓率低 ,高血压年限采用回忆法判断病情可靠性差 ;
Objective To study the relationship of variability of blood pressure with cardiac structure and functions in essential hypertension.Methods A hundred and ten patients suffered from essential hypertension were divided into two groups according whether having left ventricular hypertrophy. The characteristics of overload and variability of blood pressure in both groups were analysed and several indexes on cardiac structure and function were compared between two groups. Results Both groups showed significant differences in the mass of left ventricle (LVM), the mass index (LVMI) of left ventricle, the thickness of interventricular septum (IVS), posterior wall of left ventricle (LVPW) and relative wall thickness (RWT) except for hypertensive ages. The ratio of E/A in both groups was significantly decreased. The rate of SBP load (SBPLO) both at day and night, the level of SBP in 24 hours and reductive rate of SBP at night (nSBPrr), the variabilities of systolic blood pressure (SBPV) and mean arterial pressure (MAPV) as well as hypertensive vascular overload index (HTNVOI) in two groups were obviously different. Conclusions 1) In early stage, the diastolic cardiac function in essential hypertension was damaged. 2) The happeness of left ventricular hypertrophy in essential hypertension was not only associated with the degrees and types of vascular overload, the increased variabilities of systolic blood pressure and mean arterial pressure, reversely with the reductive rate of SBP at night as well, but feebly with hypertensive age. 3) As a low awareness, hypertensive age was unreliable in the recollection. 4) Age was also a risk factor of left ventricular hypertrophy in essential hypertension.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2001年第4期296-299,共4页
Chinese Journal of Epidemiology
