摘要
目的：探讨血管内皮生长因子（ＶＥＧＦ）和微血管密度（ＭＶＤ）与乳腺浸润性导管癌腋窝淋巴结转移的关系。方法：采用ＬＳＡＢ法对６５例浸润性导管癌术后根治标本，进行ＶＥＧＦ的表达和微血管密度的测定。结果：６５例乳腺癌的 ＭＶＤ为（４７．６±２２．４）个，ＶＥＧＦ总阳性率为 ８０．００％；ＶＥＧＦ、ＭＶＤ与淋巴结转移有关，在腋窝淋巴结转移的乳腺癌组织中，ＶＥＧＦ的阳性率 ８８．８９％（３２／３６），ＭＶＤ（５６．６±２０．５），均明显高于无腋窝淋巴结转移者ＶＥＧＦ的阳性率 ６８．９６％（２０／２９），ＭＶＤ（３１．３±１８．９）．差异有显著性（Ｐ＜０．０５）；ＶＥＧＦ和 ＭＶＤ在乳腺浸润性导管癌中的表达具有显著的正相关（ｒ＝８.２１３，Ｐ＜０．０５）。结论：ＶＥＧＦ与乳腺癌血管生成密切相关；ＶＥＧＦ表达的增高及 ＭＶＤ的增加对乳腺癌腋窝淋巴结转移可能有促进作用。
Objective: To investigate the relationship of vascular endothelial growth factor (VEGF ) and microvascular density (MVD ) with the axillary lymph node metastasis in breast carcinoma. Method: LSAB immunohistochemical method was used to detect the VEGF expression in 65 cases with invasive ductal carcinoma after the surgical treatment. Results: The average MVD was 47. 6±22. 4 and the positive rates of VEGF was 80.00%. Both of them was correlated with the metastasis of the cancer to axillary lymph node. The positive rate of VEGF and MVD were significantly higher in those with axillary lymph node metastasis than that in patients without metastasis(P＜0.05 ). There was a close positive correlation between VEGF and MVD in invasive ductal cacinoma of breast (r= 8.213, P＜0.05 ). Conclusion VEGF is highly related with the angiogenesis of breast carcinoma. The increase of VEGF and MVD may play a role in the promotion of the axillary lymph node metastasis of breast carcinoma.
出处
《广州医学院学报》
2001年第2期37-39,共3页
Academic Journal of Guangzhou Medical College
关键词
乳腺癌
血管内皮生长因子
血管生成
微血管
腋窝淋巴结转移
breast carcinoma
vascular endothelial growth factors
angiogenesis
neovascularization/ pathologic
