摘要
目的：研究Ｐ－糖蛋白（Ｐ－ｇｌｙｃｏｐｒｏｔｅｉｎ，Ｐｇｐ）在乳腺癌组织中的表达，评估其在乳腺癌预后中的作用。方法：采用免疫组织化学方法（Ｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｓｔｒｙ，ＩＨＣ ）检测４７例手术切除的乳腺癌组织中Ｐｇｐ的表达，并分析其与临床、病理特征的关系及对预后的影响。结果：Ｐｇｐ在乳腺癌组织中的总表达率为８３．０％ （３９／４７例），高表达者占５３．２％（２５／４例），其与月经状况、肿瘤大小、淋巴结转移、组织分级和激素受体状况均无关（Ｐ＞０．０５）；Ｋａｐｌａｎ－Ｍｅｉｅｒ生存分析结果表明 Ｐｇｐ表达与无病生存期和总生存期均显著相关（ Ｐ＜０．０１），而多因素 Ｃｏｘ分析却显示仅有Ｐｇｐ和淋巴结转移是独立的预后因素。结论：Ｐｇｐ在乳腺癌组织中具有较高的表达，有可能成为判断乳腺癌预后的有用指标。
Objective: To study the relationship between the expression of multidrug resistance gene production P-Glycoprotein (Pgp) with the clinicopathological characteristics and the prognosis in primary breast cancer patients. Methods: Expression of Pgp in 47 breast cancer patients were determined by immunohistochemistry on formalin-fixed, paraffin-embedded tumor section. Results: Pgp expression was observed in 39 of 47 (83.0%) patients. No relation could be established between expression of Pgp and other clinicopathological parameters. Kaplan-Meier analysis revealed that patients with Pgp-negative cancers had prolongation of overall survival (OS) and disease-free survival (DFS). In multivariate Cox regression analysis, only Pgp and lymph node metastasis were independent prognostic factors for OS. Conclusion: The results suggest that Pgp is frequently expressed in primary breast cancer, and Pgp might be used as one of the markers of poor prognosis in patients with breast cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2001年第5期325-328,共4页
Chinese Journal of Clinical Oncology
基金
国家"九五"攻关项目基金资助(编号:96-906-0l-23)
