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中国苗族人群中细胞色素P450 2C19基因多态性的研究 被引量:11

Cytochrome P450 2C19 Gene Polymorphism in Chinese Miao Population
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摘要 为研究细胞色素P45 0 2C19在中国苗族人群中的基因型 ,采用聚合酶链式反应与限制性内切核酸酶片段长度多态性技术分析了 98例无血缘关系苗族人群的基因型。结果显示 5 0人为CYP2C19野生型纯合子 (wt/wt) ;39人为CYP2C19m1杂合子 (wt/m1) ;9人为CYP2C19m1突变型纯合子 (m1/m1)。与国内外相关报道比较 。 In order to study the cytochrome P450 2C19 gene polymorphism in Miao population, the genotypes of ninety eight unrelated Miao subjects were studied by polymerase chain reaction and restricted fragment length polymorphism (RFLP). The results showed that fifty were homozygous for wild type ( wt/wt ); thirty nine were heterozygous for the CYP2C19 m1 (wt/m1 );nine were homozygous for CYP2C19 m1(m1/m1 ).The frequency of CYP2C19 m1 was in agreement with that of other published data.
出处 《遗传》 CAS CSCD 北大核心 2001年第3期192-194,共3页 Hereditas(Beijing)
基金 国家科技部计划生育专项基金!资助 编号 :998672
关键词 细胞色素P4502C19 基因型 聚合酶链式反应 性内切核酸酶片段长度多态性 苗族人群 cytochrome P450 2C19 genotype polymerase chain reaction restricted fragment length polymorphism(RFLP)
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