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氯化饮用水致突变性检测方法敏感性的研究 被引量:9

Experimental Study on the Sensitivity of the Short-term Genotoxicity Assays for Detecting Mutagenic Activity of Chlorinated
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摘要 本文以商品腐殖酸溶液的氯化为实验模型,在严格控制的实验条件下,比较了Ames试验、体外中国仓鼠卵巢(CHO)细胞姊妹染色单体互换(SCE)试验和体外CHO细胞微核试验在检测氯化饮水致突变性中的敏感性。结果表明体外CHO细胞SCE试验最为敏感,体外CHO细胞微核试验其次,Ames试验敏感性相对较差。根据本研究结果,我们建议在以一般地面水为水源的氯化饮水的致突变性检测中,可首选体外CHO细胞SCE试验。 In this study, the sensitivity of the Ames test, of the sisterchromatid exchange (SCE ) assays and the micronucleus ( MN ) assay in cultured Chinese hamster ovary ( CHO ) cells in vitro was compared with the model of chlorinated humic acids. The results showed: the SCE assay was the most sensitive, the MN assay Was the second sensitive, the Ames test was relatively less sensitive than the SCE and the MN assay. According to this experimental result, we recommend that the SCE assay may be used first for detecting mutage-nic activity of chlorinated drinking Water where its suiface Water sources Was not contaminated by industrial pollutants.
出处 《环境与健康杂志》 CAS CSSCI CSCD 北大核心 1991年第3期107-110,共4页 Journal of Environment and Health
关键词 饮用水 致突变性 检测方法 敏感性 Drinking water Mutagentc activity Sensitivity, shortterm genotoxicity
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