摘要
目的 探讨顺势疗法治疗慢性乙型肝炎的疗效。方法 慢性乙肝患者单用干扰素治疗 42例 ,干扰素联合草分子杆菌FU36 (Utilin’s ,乌体林斯 )治疗 37例 ,临床观察、随访 6个月 ,用免疫比色法检测血清ALT、TB和乙肝病毒标志物。结果 治疗 2个月后 ,单用干扰素组HBeAg转阴率为 35 7% ,顺势治疗组为 48 6 % ,均高于自然转阴率。顺势治疗组肝功能恢复优于单用干扰素组 (P <0 0 5 ) ;治疗 6个月后 ,HbeAg与HBVDNA转阴率单用干扰素组分别为 2 1 4%和 16 7% ,顺势治疗组则分别为 42 2 %和 37 8%。结论 乌体林斯联合干扰素治疗慢性乙肝患者较单用干扰素治疗 ,提高了肝功能复常率、降低HBeAg阳转率。
Objective To explore the efficacy of combination therapy in the treatment of chronic hepatitis B. Method 37 patients with chronic hepatitis B received Utilin’s/interferon combination therapy,and 40 cases with interferon monotherapy comprised the control group.The whole course lasted for 6 months,and the response parameters including alanine aminotranferase,bilirubin,HBV DNA,HBeAg and so on were followed up.Result After 2 months of therapy,HBeAg seroconversion was observed in 48.6% of combination therapy patients as compared to 35.7% in the monothrapy group,and both rates were higher than spontaneous seroconversion rate.Biochemical features of chronic hepatitis B in combination therapy group were normalized better than that of control group(P<0.05).After completing 6 months of therapy,the negativization rates of HBeAg and HBV DNA in combination therapy group were 43.2% and 37.8% respectively,while those of monotherapy were 21.4% and 16 7% respectively.Conclusion compared to interferon monotherapy,Utilin’s interferon combination therapy normalized biochemical features of chronic hepatitis B better,and decreased appearance rate of HBeAg.
出处
《杭州医学高等专科学校学报》
2001年第2期77-79,共3页
Journal of Hangzhou Medical College
