摘要
随着透皮吸收研究的兴起,先后已有东茛菪碱、硝酸甘油、硝酸异山梨醇、可乐定和雌二醇等透皮给药系统进入市场。各生产单位对这些产品都有一定的质量控制项目,主要有药物含量、粘附力及药物释放速率,其中药物的释放速率是一个较重要的质量控制项目。
The release profiles of nitroglycerin transdermal Patches were determined by using the paddlemethod in dissolution apparatus and diffusion cell method. The release rates of five brands in bothmethods were compared and discussed. The results obtained indicate that both methods candistingnish the different release behaviour of various type of transdermal nitroglycerin patch, andthe dissolution method was found to be simple and applicable. It was suggested that the cumulat-ive amounts released at 1, 8 and 24 hr were determined to express 'burst effect' of drugcontrolled release rate and total amount released, respectively.
关键词
硝酸甘油
透皮给药
体外释药速率
Transdermal Delivery System
Nitroglycerin
Dissolution Rate
