摘要
血管腔内放疗预防经皮穿刺冠状动脉血管成形术 (PTCA)后再狭窄的临床应用取得了令人瞩目的疗效。人们认为 ,射线预防 PTCA后血管再狭窄主要是射线对血管平滑肌细胞产生的抑制作用 ,但是这种抑制作用的机制尚不十分清楚 ,目前认为最关键的因素是射线抑制了血管平滑肌细胞的迁移和增殖 ,凋亡在射线抑制再狭窄过程中所起的作用尚存在争议。在这个过程中 ,射线对巨噬细胞和多种细胞因子的抑制作用也逐步受到人们的重视。
Endovascular radiation is a promising technique to substantianlly reduce the restenosis post PTCA. Inhibition of VSMCs by radiation is thought as the main cause, but the machanism of this is not clear. Inhibition of VSMCs proliferation and miagration by radiation is ragarded as the most important factor. The role of apoptosis in this couse is not determined. However, inhibition of macrophage and cytokines by radiation is emphasized recently.
出处
《国外医学（放射医学核医学分册）》
2001年第1期27-30,共4页
Foreign Medical Sciences(Section of Radiation Medicine and Nuclear Medicine)
基金
国家自然科学基金!资助项目 (3 990 0 1 67)
关键词
血管内照射
再狭窄
血管平滑肌细胞
经皮穿刺冠状动脉成形术
endovascular radiotherapy
restenosis
vascular smooth muscle cells
percutaneous transluminal coronary angioplasty
