摘要
118例Graves病初发患者,用他巴唑治疗6月,停药后随访1年,51例缓解,67例复发。结果表明,治前的血清T_3、T_3/T_4比率及治疗结束时的T_3,在复发组与缓解组之间均有统计学差异(P<0.0005,0.005及0.025).而血清T_4,无论治前或治末,均无统计学差别(P>0.05).血清T_3/T_4比率是否与预后有关,其实质是取决于血清T_3,尤其是治前的血清T_3。
118 new patients with Graves' disease were treated by methimazole for 6 months and follow-up for another 12 months. The initial dose was 30 mg/d. Bisochemical euthyroidism was achieved within 1-3 months after taking medicine and maintenance dose was given until cessation of the treatment. The results of 1 year follow-up after the withdrawal of drugs showed that of 118 patients, 67 had relapsed, with a recurrence rate of 56.8%, the remaining 51 (43.2%) were in remission. The serum T_3 before and at the end of treatment and T3/T4 ratio before therapy were significantly different between the groups of relapse and remission (p<0.0005, 0.025 and 0.005 respectively), but no significant difference in serum T3/T4 ratio at the end of therapy. The serum T3/T4 ratio is an unstable index and was affected by serum levels of T3 and T4, but serum T3 level before antithyroid drug therapy is a rather reliable parameter to predicting the outcome of hyperthyroidism due to Graves' disease
出处
《华西医学》
CAS
北大核心
1991年第3期258-261,共4页
West China Medical Journal
关键词
甲状腺肿
T3/T4比率
预后
Graves' disease
Triiodothyronine (T3)
Thyroxine(T4)
T3/T4 ratio
Prognosis
