摘要
综述了近年对乙型肝炎病毒(HBV)变异株的复制、免疫学特性、致病性、耐药性等功能基因 组研究及其临床意义的研究进展,阐述基因组水平研究HBV变异株功能的重要性及有关结果,展望今 后HBV变异株生物学特性研究的方向。
The recent progress on functional genomics and clinical implications of hepatitis B virus (HBV) variants was reviewed, focusing on the replication, antigenicity, immunogenicity, pathogen esis and anti-viral drug resistance of the variants. The importance revealed by functional studies of the variants based on full-length genomics studies was presented. Future development of functional studies of the variants was discussed.
出处
《生命科学》
CSCD
2001年第3期110-112,99,共4页
Chinese Bulletin of Life Sciences
基金
国家基础研究 973 项目(G1999054105)
国家自然科学基金重点项目(39630020)
上海市科技发展基金(98J
关键词
乙型肝炎病毒
基因变异
复制
抗原性
免疫原性
hepatitis B virus (HBV)
gene mutation
replication
antigenicity
immunogenecity