摘要
目的和方法 :采用溶血实验 ,小鼠肝组织脂质过氧化物 (MDA)测定 ,采用受辐射质粒构象改变等方法测定从生姜中分离得到的一新的环状二苯基庚烷类化合物 (化合物 1)的抗氧自由基损伤活性。结果 :化合物 1能显著抑制H2 O2 致人红细胞溶血作用 (P <0 0 1) ;明显抑制小鼠肝组织脂质过氧化物 (MDA)的产生 (P <0 0 1) ;显著抑制受辐射质粒超螺旋构象百分率的下降 (P <0 0 5或P <0 0 1)。结论 :化合物
AIM: To assess the antioxidative activity of a new cyclic diaryheptanoid (compound 1) from ginger on free radical damage. METHODS: Hemolysis, MDA levels of mice liver tissue homogenates, the conformation changes of irradiated PUC 18 were used as indices. RESULTS: Compound 1 significantly reduced the hemolysis of human red blood cells induced by H 2O 2 ( P<0.01 ) and MDA level in the liver of mice ( P<0.01 ), raised the percentage of the supercoil conformation of plasmid PUC 18 induced by [ 60 Co]γ-rays ( P<0.05 or P<0.01 ).CONCLUSION: Compound 1 had a good activity on suppressing oxygen free radical damage.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2001年第5期461-463,共3页
Chinese Journal of Pathophysiology
