摘要
目的 探讨心血通对兔急性心肌缺血再灌注性心律失常及其血浆内皮素浓度的影响。方法 2 7只兔随机分为对照组、治疗组和预防组。 3组兔均用乙醚麻醉 ,开胸结扎左前降支冠状动脉(LAD) 60min ,然后松开LAD再灌注 12 0min ,用心电监护仪观察心律失常发生情况 ,在LAD结扎前、及LAD结扎后 10min ,2 0min ,4 0min ,60min及再灌注后 10min ,2 0min ,4 0min ,60min ,12 0min采血测定ET浓度。结果 预防组显著降低各相同时相点血浆ET浓度 (P <0 .0 1) ,显著降低缺血再灌注性心律失常发生率。而治疗组和对照组作用不明显。结论 心血通对再灌注心律失常有预防作用 ,而无治疗作用 ,其机制与ET浓度下降有关。
Objective To investigat the effects of Xinxuetong on arrhythmias and endothelin (ET) concentration in plasma during myocardial ischemia reperfusion.Method 27 rabbits were divi ded into 3 groups,control group (n=9),treatment group (n=9) and prevent group (n=9).All rabbits were anesthesiaed by ether,27 rabbits with open chest were underwent 60 minutes occlusion of the left anterior descending coronary artery followed by 120 minutes of reperfusion.To observe arrhythmias by cardioelectrographic monitoring.Blood samples were collected before ischemia,at 10,20,40,60 minutes during ischemia,and at 10,20,40,60,120 minutes during reperfusion in 3 groups.Plasma ET concentration were measured.Result Plasma ET concentration and arrhythmias in prevent group were significantly lower than control group and treatmeng group in same time (all P<0.01).Conclusion Xinxuetong has its function of preventing on myocardial ischemia reperfusion,no treating.It may be associated with reduction of plasma ET concentration. [
出处
《潍坊医学院学报》
2001年第2期103-105,共3页
Acta Academiae Medicinae Weifang
关键词
心血通
心肌缺血
再灌注
心律失常
内皮素
Xingxuetong
Myocardial ischemia
Reperfusion
Arrhythmia
Endothelin
