摘要
目的 :探讨甲型与戊型肝炎肝细胞损害程度的差异和检测血清 β2 -微球蛋白 ( β2 -MG)的临床意义。方法 :对血清β2 -MG水平与发病年龄、血清主要生化指标作相关分析 ,对甲型与戊型肝炎血清β2 -MG水平进行比较。结果 :血清β2 -MG水平与发病年龄无相关性 ( P >0 .0 5 ) ;戊型肝炎血清 β2 -MG水平显著高于甲型肝炎 ( P <0 .0 1) ;血清 β2 -MG水平与丙氨酸转氨酶和总胆红素均无相关性 ( P >0 .0 5 ) ,与白蛋白呈负相关 ( P <0 .0 0 1)。结论 :发病年龄对血清β2 -MG水平无明显影响 ;戊型肝炎肝脏炎症和损害程度较甲型肝炎重 ;检测血清β2 -MG可间接反映肝细胞损害程度 ,但不是判断肝细胞损害程度的敏感指标。
Objective: It is to explore the difference of degree of liver impairment between hepatits A and hepatitis E, and the clinical significance of serum microglobulin (β 2 MG) detection. Methods: The correlation between the level of serum β 2 MG and the age of flare up, the level of alanine aminotransferase, the level of total bilirubin, the level of albumin were analyzed. The level of serum β 2 MG in hepatitis A was compared with that in hepatitis E.Results: The level of serum β 2 MG was not related to the age of flare up (P>0.05). The level of serum β 2 MG in hepatitis E was notably higher than that in hepatitis A (P< 0.01 ). The level of serum β 2 MG was not related to the level of alanine aminotransferase and that of total bilirubin (P>0.05). There was notably negative correlation between the level of serum β 2 MG and the level of albumin (P<0.001). Conclusion: The age of flare up has no effect on the level of serum β 2 MG. Liver impairment in hepatitis E is more severe than that in hepatitis A. The level of serum β 2 MG could reflect the degree of liver impairment, but it is not a sensitive index in judging the degree of liver impairment.
出处
《现代中西医结合杂志》
CAS
2001年第9期794-795,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
