摘要
评价后程加速放疗对食管癌病人的疗效。材料与方法自１９９１年１０月至１９９３年５月对１００例食管癌病人进行了研究，随机分为两组：常规组（５０例），后超组（５０例）。两组包括颈段４例，胸上段３５例，脾中段５６例及胸下段５例。全部病人均为鳞癌。常规照射：１８０－２００ｃＧｙ／次，５次／周，总量６０００ｃＧｙ／６周；后程加速照射：前３周同常规组，共３０００ｃＧｙ／３周，第４周起，１５０ｃＧｙ／次，日２次，间隔６小时，照射量为３０００ｃＧｙ／２周，总照射量６０００ｃＧｙ／５周。结果局控率后超组９８％（４９／５０），常规组９４％（４７／５０），１，２，３年生存率分别为８４％（４２／５０）、５６％（２８／５０）、４８％（２４／５０）及６２％（３１／５０）。３４％（１７／５０）２２％（１１／５０），后超组明显好于常规组（Ｐ＜０．０１）。两组放疗副反应无差别，其主要死因是局部复发、次为出血、穿孔及远处转移，后超组死于出血、穿孔者并不多于常规组。结论后程加速照射能明显提高食管癌病人１，２，３年生存率，不增加放疗副反应及并发症。
Purpose To evaluate the effect of late course accelerated radiation for esophagus carcinoma Materials and Methods 100 patients with esophagus carcinoma were treated from October 1991 to May 1993 . They were randomly divided into two groups : late course hyperfraction radiation ( LCHR ) group ( 50 patients) and conventional fraction radiation ( CFR ) group ( 50 patients) , All were squamous. cell carcinoma . Patients in CFR received 1 80 cGy to 200 cGy/ per fraction, five fractions/ per week with the total doses of 6000 cGy /6 weeks. Patients in LCHR received 150 cGy/per fraction, two fractions/per day with 6 hours interval and 3000 cGy/2 weeks The total doses of 6000 cGy/5 weeks. Results The local control rates were 98 % in LCHR group and 94 % in CFR group , There was not significant difference between two groups , The one, two and three - year survival rates were 84 % (42/50) , 56 % (28/50 ) , 48 % (24/50 ) in LCHR group and 62 % ( 31/ 50),34%(17/50),22% (11/50) in CFR group, respectively. The survival rates in LCHR group were much better than that in CFR group (P < 0 . 01 ) .There was no significant difference between two groups about clinical radiotherapy symptoms . No differences of subsequent causes ( such as bleeding , fistula ) were found in both groups. Conclusion The survival rates of patients with esophageals carcinoma can be improved by LCHR without increasing any complication .
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
1997年第1期16-18,共3页
Chinese Journal of Radiation Oncology
关键词
食管癌
后程加速
放射治疗
生存率
疗效
Esophagus carcinoma Late course accelerated Hyperfraction radiation
