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54例原发胃非何杰金淋巴瘤预后因素分析 被引量:2

Analysis of prognostic factors in primary gastrointestinal non-Hodgkin's lymphoma: A study of 54 patients
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摘要 目的 :分析原发胃非何杰金淋巴瘤 (PG- NHL )经不同方法治疗后的结果及预后因素。材料与方法 :1984年~ 1992年共收治 5 4例 PG- NHL ( 期 19例 , 期 2 3例 , 期 6例 , 期 6例 .4 5例作胃根治术 ,7例作探查术 .术后无辅助治疗 2例 ,4 3例作放疗、化疗或放疗加化疗综合治疗。结果 : ~ 期 5年生存率分别为 94 .7%± 13.5 %、79.1%± 12 %、80 .0 %± 2 5 .3%和 16 .7%± 15 .2 % (生命表法μ检验 )。影响预后的主要因素是病理分期与术后辅助治疗的策略 ,其次是原发肿瘤的体积、单发或多发。结论 :肿瘤侵及粘膜层或浅肌层属于 期早 ,根治术后有 /无辅助治疗 ,其疗效相同。已侵及胃全层的 期晚和 期应作全腹放疗 , 期宜先放疗后化疗 , 期应先化疗后放疗的综合治疗。放疗腹部中平面剂量为 4 0~ 4 5 Gy,化疗常用阿霉素、环磷酰胺、长春新碱、平阳霉素和强的松 (CHOP- BLM)的方案 ,4~ Purpose: To analyze the treatment results and detect the prognostic factors for primary gastrointestinal non-Hodgkin'slymphoma (PG-NHL) treated by various treatments. Materials and Methods: 54 PG-NHL patients (19 stage Ⅰ,23 stage Ⅱ, 6 stage Ⅲ and 6 stage Ⅳ patients) were treated from 1983 through 1992. After exploratory,45 patients had gastrotomy and 7, laparotomy. 43 patients were treated by postoperative radiotherapy or chemotherapy or both. Results: The 5-year survival rates ofⅠ~Ⅳ stage were: 94.7%±13.5% ,79.1%±12%, 80%±25.3% and 16.7%± 15.2%. The prognostic factors in PG-NHL were clinical pathologic stages, the volume of the primary tumor and single or multiple foci. Conclusion: Adequate initial surgery combined with postoperation adjunctive R in the upper abdomen for early stage Ⅰ and total abdomen for late stage Ⅰ and Ⅱ, which could be combination C+R following the incomplite resection or unresectable lesions , the tumor dose were 40~45Gy/5~6 wks and the CHOP- BLM program 4~ 6 cyles are benefit for PG-NHL.
出处 《中华放射肿瘤学杂志》 CSCD 1996年第1期25-28,共4页 Chinese Journal of Radiation Oncology
关键词 胃肿瘤 根治术 非何杰金淋巴瘤 综合治疗 预后 PG-NHL Gastric gastrointestinal Non-Hodgkin's lymphoma Combination therapy
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  • 1谷铣之 ... ..肿瘤放射治疗学[M],1993.

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