期刊文献+

人类HSV-2对小鼠白血病病毒诱发小鼠白血病的促进作用 被引量:1

Enhancing Effect of Human Herpes Simplex Virus Type 2 on Induction of Leukemia with Murine Leukemia Virus in Mice
原文传递
导出
摘要 本实验研究证明紫外线灭活的人类单纯疱诊病毒Ⅱ型(HHSV-2)可以提高小鼠白血病病毒(MuLV)在新生小鼠中诱发白血病的发病率。单独接种 MuLV和接种 HHSV-2+MuLV的小鼠中白血病的发病率分别是44.74%(17/38)和75.00%(27/36),其差异具有高度显著性(P<0.01).此动物模型可用于研究 MuLV 与 HHSV-2在诱发恶变过程中二者之间相互作用的原理. This experimental study demonstrated that UV-inaetivated human herpes simplex virus type 2(HHSV-2)enhanced the incidence of leukemia_2~ induced with murine leukemia virus(MuLV)in newborn mice.Seventeen out of 38 newborn mice inoculated with MuLV alone and 27 out of 36 newborn mice inoculated with UV-inactivated HHSV-2 Plus MuLV were found to develop leukemia.The percentage increased from 44.74%to 75.00%.There was a highly significant difference between them(P<0.01).This animal model might be used for studying the mechanism of an interaction between MuLV and HHSV-2 in induction of malignancies.
出处 《湖北医学院学报》 1991年第1期17-24,共8页
关键词 人疱疹病毒 白血病病毒 白血病 herpesvirus,hominis avelson leukemia virus leukemia,experimental mice animals,laboratory
  • 引文网络
  • 相关文献

参考文献4

  • 1刘建军,陈敏诲,张蔚英.单纯疱疹病毒Ⅱ型与白血病病毒协同诱发小鼠淋巴细胞白血病的初步观察[J]湖北医学院学报,1985(01). 被引量:1
  • 2赏诗樟.单纯疱疹病毒Ⅱ型紫外线照射后的生物学特性[J]微生物学报,1983(04). 被引量:1
  • 3陈敏诲,孙瑜,张友新,张蔚英.重复感染疱疹二型病毒吴株诱发小白鼠宫颈癌的实验研究[J]实验生物学报,1980(03). 被引量:1
  • 4F. Rapp,Nancy Turner. Biochemical transformation of mouse cells by herpes simplex virus types 1 and 2: Comparison of different methods for inactivation of viruses[J] 1978,Archives of Virology(1-2):77~87 被引量:1

同被引文献2

  • 1刘建军,陈敏诲,张蔚英.单纯疱疹病毒Ⅱ型与白血病病毒协同诱发小鼠淋巴细胞白血病的初步观察[J]湖北医学院学报,1985(01). 被引量:1
  • 2F. Rapp,Nancy Turner. Biochemical transformation of mouse cells by herpes simplex virus types 1 and 2: Comparison of different methods for inactivation of viruses[J] 1978,Archives of Virology(1-2):77~87 被引量:1

引证文献1

;
使用帮助 返回顶部