摘要
聚酸酐是一类新型的药物控制释放载体材料，具有良好的生物相容性和表面溶蚀性能［１］．聚酸酐的降解和药物释放速率可通过改变单体结构、共聚物的组成和主链上的酸酐键密度实现．后者主要是把降解速率不同的酯键、酰（亚）胺键和磷酸酯键引入主链上，合成主链上有多种可...
Polymeric drug containing active agent in the backbone was one of the controlled release systems. In this paper, some polymers, which have an antineoplastic agent(hexestrol) in the backbone, have been synthesized by copolymerization hexestrol bis(hydrogen succinate) with sebacic acid(SA). Hexestrol bis(hydrogen succinate) was prepared by reaction hexestrol with succinic anhydride. The degradation properties in vitro under various pH conditions were also investigated. The results showed that the degradation rates increase with the increase of pH, and at the same time, the degradation rates increase with the increase in sebacic acid content in the copolymers.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第6期990-992,共3页
Chemical Journal of Chinese Universities
基金
湖北省自然科学基金
