摘要
目的 应用细胞增殖指标核仁组成区相关嗜银蛋白(ＡｇＮＯＲｓ),研究兔眼滤过道成纤维细胞(Ｆｂ)增殖规律及丝裂霉素Ｃ(ＭＭＣ)的抗增殖作用,并对其临床意义进行探讨。方法取兔眼滤过道切片作ＡｇＮＯＲｓ及ＨＥ染色,比较ＭＭＣ眼和对照眼Ｆｂ ＡｇＮＯＲｓ染色颗粒数量。结果不同手术区ＭＭＣ眼Ｆｂ ＡｇＮＯＲｓ颗粒数显著低于对照眼,ＭＭＣ抑制率为５０．７％～８２．１％。结论丝裂霉素Ｃ可以有效抑制咬切口、巩膜瓣下、结膜瓣下Ｆｂ的增殖活性,抑制作用稍强于同类药物５－Ｆｕ。
Objective To investigate the regularity of fibroblast (Fb) proliferation and the effect of Mitomycin C(MMC) after filtration surgery in rabbits. MethodsHistochemistry method of AgNORs and HE was used to count the Fb AgNORs granules of MMC eyes and control eyes.ResultsThe AgNORs granules were statistically different between MMC eyes and control eyes,the suppressive rate was from 50.7% to 82.1%.ConclusionMMC can suppress effectively the activity of Fb which proliferated in sclerectomy area, subscleroflap area and subconjunctivoflap area .
出处
《眼科研究》
CAS
CSCD
北大核心
2001年第2期114-115,共2页
Chinese Ophthalmic Research
基金
陕西省自然科学基金资助!(项目编号:96SM42)
