摘要
目的 :探讨促炎细胞因子和抗炎细胞因子在急性胰腺炎 (AP)发病机制中的作用。方法 :应用 EL ISA法检测 4 8例病人血液中促炎细胞因子 (TNF 、IL- 1β、IL- 6、IL- 8)和抗炎细胞因子 (IL- 10、IL- 1ra)。结果 :AP病人血液中促炎细胞因子和抗炎细胞因子在早期持续显著升高 (与正常对照组相比 P<0 .0 5 ) ,其后逐渐下降 ,并与临床症状变化的时相一致。结论
Purpose: To study the pathogenic role of pro and anti inflammatory cytokines in the development of acute pancreatitis(AP). Methods: TNF, IL β, IL 6, IL 8, IL 10 and IL 1ra in plasma in 48 patients with AP and 20 healthy persons were detemined by ELISA. Results: The level of pro and anti inflammatory cytokines in plasma in AP patients was significantly higer than that in control group (P< 0.05 ) early in the disease process, and then was decreacing gradually. However the dynamic changes of pro and anti inflammatory cytokines were closely related to the clinical symptoms of the patients with AP. Conclusion: The pro and anti inflammatory cytokines might all play a key role in the development of AP.
出处
《临床消化病杂志》
2001年第2期51-53,共3页
Chinese Journal of Clinical Gastroenterology
