摘要
目的 研究新生儿窒息缺氧所致全身多脏器损伤 ,尤以肾脏受损发生率最高。方法 本文实验组35例窒息新生儿 ,分别采集第 1d、第 5d2次尿标本 ;对照组 2 9例健康新生儿 ,采集生后第 1d尿液。测量反应肾小管功能的 β2 微球蛋白 ,视黄醇结合蛋白 ,N -乙酰 - β -D -氨基葡萄糖苷酶 ;反应肾小球功能的转铁蛋白与白蛋白。实验组与对照组取生后 1d的静脉血 ,测尿素氮和肌酐的含量。对上述各指标进行比较。结果与结论 β2 -MG较RBP灵敏 ,RBP较NAG灵敏 ;TRF与A1b具相似灵敏性 ;在反应肾脏受损的各个指标中 ,BUN与Scr的灵敏性最差 ;肾小球功能恢复较肾小管恢复快。
Asphyxia of the neonate may lead to multiple organ injuries especially the renal damage because of its higher incidence. The urine samples of 35 neonates in experimental group with asphyxia were collected at 1st and 5th day after birth. The urine samples of 29 healthy neonates in control group were taken at 1st day after birth. β2-microglobin (β2-MG) and retinal binding protein (RBP), N-acetyl-β-D-glucosaminidase (NAG) were detected as indicators to reflect renal tubular function. Urinary transferrin (URF) and albumin (Alb) were detected as indicators of renal glomerular function. The vein blood samples of both groups were collected at 1st day after birth and the content of urea nitrogen and creatinine were detected. The results showed that β2-MG was more sensitive than RBP in reflecting renal tubular injury and RBP was more sensitive than NAG. TRF had similar sensitivity with Alb in reflecting renal glomerular injury. The sensitivities of Bun and Scr were the least among these markers that reflect renal injury. Renal glomerular function could be recovered faster than renal tubular function.
出处
《黑龙江医学》
2001年第4期242-243,共2页
Heilongjiang Medical Journal
