摘要
目的 通过测定急性感染患者与急性感染性多脏器功能障碍综合征 (MODS)患者血浆中AT -Ⅲ活性变化 ,探讨AT -Ⅲ活性变化对预测急性感染MODS发生与预后的临床意义。方法 急性感染患者 136例 ,将其分为 2组 ,非MODS组 10 8例 ,MODS组 2 8例。应用凝血酶凝胶空斑方法测定血浆中AT -Ⅲ活性。结果 正常人组为 90 3± 2 6 4,急性感染组为 71 2 9± 8 5 9,非MODS组为 76 12± 10 2 1,MODS组为 5 4 2 1± 5 14;急性感染组AT -Ⅲ活性低于正常人组 (P <0 0 5 ) ,MODS组AT -Ⅲ活性明显低于非MODS组 (P <0 0 1)。结论 急性感染早期AT -Ⅲ活性开始降低 ,MODS发生时AT -Ⅲ活性明显降低 ,AT -Ⅲ活性测定具有预测急性感染MODS发生的可能性及其预后判断有一定临床意义。
Objective To study the relationship between the plasma concentration of AT-Ⅲ and prognosis in patients with acute infection and multiple organ dysfunction syndrome(MODS).Methods We have 136 patients with acute infection in two groups,108 acute infection patients with MODS,28 acute infection patients with MODS,We determined AT-Ⅲ with thrombase-gel-spot method.Results Control group 90 3±26 4,MODS group 54 21±5 14,and non-MODS group 76 12±10 21.The plasma concentration of AT-Ⅲ in acute infection patients was lower than that of the normal people in control group (P<0 05).The concentration of AT-Ⅲ in MODS patients was significantly lower than that of the non-MODS patients(P<0 01).Conclusion In the early period of acute infection,the activity of AT-Ⅲ begin to decline.In MODS the activity of AT-Ⅲ declined significantly.So the determination of AT-Ⅲ help us to evaluate the possibility of MODS in acute infection and prognosis in these patients.
出处
《中华急诊医学杂志》
CAS
CSCD
2001年第1期11-12,共2页
Chinese Journal of Emergency Medicine
基金
国家中医局基金项目 (委托 )
北京市科技进步二等奖
