摘要
目的 探讨重性抑郁症患者α2 肾上腺能受体功能状况。方法 对 15例重性抑郁症患者 (抑郁症组 )和 15名正常人 (正常对照组 )分别进行多导睡眠脑电图检查。在第 1个快速眼运动(REM)睡眠周期结束 10min内 ,向所有被试者静脉注射可乐定 (剂量按 2mg/kg体重计算 ,并稀释于 9ml生理盐水中 ) ,比较两组的睡眠情况。结果 可乐定注射前 ,抑郁症组的REM比例 [(2 6 8±5 6 ) % ]、REM次数 [(6 8± 1 2 )次 ]及REM时间 [(12 0 6± 2 5 1)min]较正常对照组增加 [分别为(19 2± 3 3) %、(4 9± 0 8)次、(78 8± 14 4)min ;P <0 0 5 ],REM潜伏期缩短 [(6 4 1± 2 7 0 )min ,对照组为 (96 1± 2 7 0 )min];可乐定注射后 ,对两组非快速眼运动睡眠几乎无影响 ,而抑郁症组和对照组的REM比例 [分别为 (2 1 3± 4 8) %和 (13 6± 2 7) % ]、次数 [分别为 (5 3± 1 2 )次和 (3 8± 0 6 )次 ]、时间[(10 1 0± 2 4 0 )min和 (6 1 0± 10 3)min]分别较注射前减少 (P <0 0 5 ) ,抑郁症组第 1次和第 2次REM间隔时间的差值小于正常对照组 (P <0 0 1) ;而两组REM潜伏期注射前后的差异均无显著性。提示抑郁症患者REM睡眠的可乐定反映较正常对照组迟钝。结论 重性抑郁症患者可能存在α2 肾上腺能受体功能低下。
Objective To study the functional condition of α 2 adrenergic receptors in patients with major depression Methods Sleep EEG of 15 depressed patients diagnosed according to CCMD 2 R was compared with that of 15 normal controls Clonidine hydrochloride was administered intravenously within 10 minute after the first rapid eyemovement (REM) sleep period Results The percent of REM in depressive patients was higher than in controls at baseline There was no significant differences between the two groups in NREM after clonidine administration, but the percent of REM, frequency of REM and time of REM decreased in the two groups The interval between the first and the second REM period (REM1 REM2) decreased more in patients with depression than in controls( P <0 01) It was suggested clonidine had little influence on the NREM sleep, but significantly effected on the REM lantency, total REM period, and interval between REM1 and REM2, and REM sleep response to clonidine bluntly in depression Conclusion It indicates there may be deficiency of α 2 adrenergic receptors in major depression
出处
《中华精神科杂志》
CAS
CSCD
北大核心
2001年第1期31-33,共3页
Chinese Journal of Psychiatry
