摘要
目的 研究肝癌组织中细胞间粘附分子 - 1(ICAM- 1)的表达与肝癌侵袭转移的关系。方法 应用流式细胞仪检测技术检测了 2 7例人肝癌组织中 型细胞间粘附分子 - 1的表达 ,并与正常肝细胞中细胞间粘附分子 - 1的表达比较 ,进一步探讨肝癌细胞产生的 型细胞间粘附分子在肝细胞癌侵袭和转移过程中的作用。结果 2 7例肝癌组织中有 2 4例 ICAM- 1表达明显增强 ,其含量明显高于正常组织 (P<0 .0 1) ,与肿瘤大小、包膜的完整成正相关 (P<0 .0 1) ,有转移组肝癌组织中 ICAM- 1的表达明显高于无转移组。结论 ICAM- 1与肝癌的侵袭和转移有关 ,有可能作为预测肝癌转移、复发及预后的指标。
Objective To study the relationship between the intercellular adhesion molecule-1 (ICAM 1) expression of hepatocellular carcinoma (HCC) tissues and its invasion and metastasis.Methods 27 cases of HCC were tested by flow cytometer to investigate the expression of ICAM 1 and compared that with healthy liver tissues.Further searching the function of ICAM 1 in the invasion and metastasis of HCC.Results 24 cases expressed higher level of ICAM 1 than that in healthy liver tissues (P<0.01).The expression of ICAM 1 correlated with the size of tumor and the integration of tumors coat (P<0.01).The expression of ICAM 1 in invasive HCC tissues was higher than that of noninvasive HCC.Conclusion ICAM 1 correlates with the invasion and metastasis of HCC,and may acts as the scale of predict HCC metastasis.recurrence and result.
出处
《肝胆外科杂志》
2001年第1期57-58,共2页
Journal of Hepatobiliary Surgery
关键词
肝癌
肝组织
I型细胞间粘附分子
肿瘤转移
流式细胞仪
Hepatic cellular cancer (HCC)
Liver tissues
Intercellular adhesion molecule 1 (ICAM 1)
Neoplasm metastasis,Wflow cytometer.
