摘要
目的 观察急性胰腺炎 (AP)患者血浆内皮素 (ET)、钙基因相关肽 (CGRP)、血清胃泌素 (GAS)的变化 ,并探讨这三种胃肠激素在AP发病机制中的作用及其临床意义。方法 应用放射免疫法测定 2 9例AP患者治疗前 (A组 )、治疗后 (B组 )及 2 2例健康人 (C组 )血浆ET、CGRP及血清GAS水平 ,并进行组间对照。结果 A组血浆ET、CGRP、ET/CGRP、血清GAS水平与B组或C组比较 ,显著升高 (P <0 0 5或 <0 0 1) ,B组三种激素ET/CGRP与C组比较无明显差异 (P >0 0 5 )。结论 血浆ET、CGRP、血清GAS在AP时增高 ,测定血液ET。
Objective To observe changes of the endothein (ET) and cacitonin gene related peptide (CGRP) in the plasma and gastrin (GAS) in the sera of patients with acute pancreatitis (AP) and discuss the pathogenic mechanisms and their clinical significance.Method The subjects included 29 patients before treatment (A Group), after treatment (B group) and 22 normal controls (C group),sampls of blood were collected at fasting state,ET and CGRP of the plasma and GAS of the sera were measured by radioimmunoassay and were compared among these three groups.Result In group A,ET,CGRP in the plasma,ET/CGRP and GAS in the sera were higher than those in group B and in group C( P<0.05 and P<0.01 ),there were no difference between group B and group C.Conclusion GAS may relate to higher levels ezyme of pancreace in AP,and determination of these three gastrointestinal hormones in the blood is of clinical significance in patients with AP.
出处
《胃肠病学和肝病学杂志》
CAS
2001年第1期50-51,共2页
Chinese Journal of Gastroenterology and Hepatology
