摘要
目的:探讨以特发型下肢深静脉血栓(IDVT)为模式疾病,研究下肢深静脉血栓(DVT)的发病机制及遗传因素的可行性。方法:随机选择IDVT患者(病例组)与健康体检者(对照组)各120例,比较两组人口学资料、血流动力学、血常规、血生化及凝血功能等指标。结果:两组年龄与性别组成差异无统计学意义(均P>0.05),与对照组比较,病例组的股、腘静脉流速降低,股、腘静脉内径增大(均P<0.05);红细胞计数及血红蛋白含量降低,白细胞及血小板计数升高(均P<0.05);白蛋白含量降低,谷草转氨酶与肌酐含量升高(均P<0.05);红细胞沉降率、凝血酶原时间、纤维蛋白原含量及活化部分凝血活酶时间升高,而凝血酶时间减少,差异均有统计学意义(均P<0.05)。结论:下肢IDVT混杂因素少,均衡性好,是进行下肢DVT临床及遗传学研究较好的模式疾病。
Objective： To investigate the feasibility of using idiopathic deep venous thrombosis （IDVT） of the lower extremity as a model disease for research into the pathogenesis and genetic factors of lower extremity deep venousthrombosis （DVT）. Methods： IDVT patients and healthy subjects undergoing health maintenance examination were randomlyselected as case group and control group, with 120 cases in each group. The demographical data and parameters ofhemodynamics, blood routine, blood biochemistry and clotting function between the two groups were compared. Results： The difference in age and gender composition had no statistical significance between the two groups（both P〉O.O5）. In case group compared with control group, the flow velocity in the femoral and popliteal vein was decreased, and the inner diameter of the femoral and popliteal vein was increased; the red blood cell countand hemoglobin content were decreased and the white blood cell and blood platelet count were increased; the albumin level was decreased and aspartate aminotransferase and creatinine level were increased; the erythrocyte sedimentation rate, prothrombin and fibrinogen level and activated partial thromboplastin time were increased and thrombin time was decreased, and all the differences had statistical significance （all P〈0.05）.Conclusion： Because of few confounding factors and better equilibrium, lower extremity IDVT is an ideal model disease for clinical and genetic research of lower extremity DVT.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2014年第6期811-815,共5页
China Journal of General Surgery
基金
云南省科技厅应用基础研究资助项目(2010ZC123)
