摘要
目的:观察尼可地尔联合曲美他嗪治疗不稳定型心绞痛的临床疗效,并评价其安全性。方法:入选本院急诊内科住院的不稳定型心绞痛患者96例,随机分为对照组(n=24)、尼可地尔组(n=24)、曲美他嗪组(n=24)及尼可地尔联合曲美他嗪组(n=24)。对照组常规治疗,在常规用药的基础上,尼可地尔组加用尼可地尔,曲美他嗪组给予曲美他嗪,联合治疗组加用尼可地尔和曲美他嗪。治疗时间均为2周,观察比较4组治疗前后心绞痛改善程度和心电图缺血改善程度及药物不良反应。结果:对照组显效14例,有效3例,无效5例,加重2例,总有效率为70.8%;尼可地尔组及曲美他嗪组总有效率分别为83.3%(20/24)、79.2%(19/24),治疗效果优于对照组(P<0.05);联合治疗组显效17例,有效5例,无效2例,总有效率为91.7%(22/24),优于其他3组(P<0.05)。心电图ST段下降导联数和ST段压低之和以及动态心电图心肌缺血总负荷各组治疗后对比,尼可地尔组[(3.6±1.5)个、(4.0±1.6)mm、(36±10)mm×min]和曲美他嗪[(3.4±1.6)个、(3.8±1.7)mm、(38±11)mm×min],优于对照组[(4.9±2.0)个、(4.8±1.4)mm、(50±13)mm×min](P<0.05)。而联合治疗组[(3.0±1.3)个、(3.1±1.2)mm、(30±9)mm×min],均优于对照组、尼可地尔组以及曲美他嗪组,差异有统计学意义(P<0.05)。而且与其它3组比较,不良反应率无明显增加(P>0.05)。结论:在常规治疗基础上,尼可地尔联合曲美他嗪治疗不稳定型心绞痛具有较好的临床疗效,而且安全可靠。
Objective：To compare the therapeutic effect of nicorandil combined with trimetazidine on patients with unstable angina unstable angina.Method：96cases of patients with unstable angina were randomly divided into four groups which included control group（n=24）,nicorandil group（n=24）,trimetazidine group（n=24）and combined treatment group（n=24）.The control group was received routine treatment.Other groups were respectively treated with nicorandil,trimetazidine and nicorandil combined with trimetazidine,besides given above treatment the other three groups on the basis of the routine treatment.The therapeutic period was 14days.Before and after the treatment,we observed the improvement of angina and changes of Electrocardiograph（ECG）and Dynamic Electrocardiography（DCG）.Result：The angina improved more significantly in the three treatment groups than that in control group.In the aspect of ECG and DCG,the treatment groups improved significantly more in the three treatment groups than in the control group in NST,ΣST and TIB.Compared to the control group,the differences were statistically significant among nicorandil group（P〈0.05）,trimetazidine group（P〈0.05）and nicorandil combined trimetazidine group（P〈0.01）.The combined treatment group had better effect than single treatment group.There were no adverse reactions in the two drugs.Conclusion：Treatment with nicorandil or trimetazidine can improve the therapeutic effect in patients with unstable angina on the basis of the routine treatment.Combined treatment of the two drugs has optimistic effect with less adverse accidents.
出处
《临床急诊杂志》
CAS
2014年第6期328-330,333,共4页
Journal of Clinical Emergency
