摘要
高分辨核磁共振(Nuclear Magnetic Resonance,NMR)波谱是一种能够在非侵入性状态下获得生物组织分子信息的有效手段。分子间多量子相干(intermolecular Multiple-Quantum Coherence,iMQC)信号源于分子间的远程偶极相互作用,仅依赖于偶极相关距离内的磁场相对均匀性,因此可用于在不均匀磁场下获得高分辨的NMR谱。文中简要介绍了iMQC的发展历程及现状,并主要讨论了iMQC方法及其在活体及生物组织中的应用。虽然iMQC目前应用在老鼠身上比较常见,但最近的研究表明iMQC方法已被用于人体小脑的研究,将来iMQC方法将有可能应用于人体的其他器官以及其他的动物研究,具有广阔的发展前景。
High resolution nuclear magnetic resonance （NMR） spectroscopy offers an effectively noninvasive method to obtain molecular information in biological tissues. Intermoleeular multiple - quantum coherences （iMQCs） originating from distant dipolar interactions between spins just rely on the relative homogeneity of magnetic field within the dipolar correlation distance. Therefore, iMQC can acquire high -resolution NMR spectroscopy in inhomogeneous fields. In this review, the development history and current situation of iMQC were briefly introduced, and the applications of iMQC on in vivo biological tissues were mainly discussed. Although it is more common to apply iMQC in mice/rats, recent investigation indicated that iMQCs can also been used in the study of human cerebellums. In the future, iMQC may be applied to study other organs of human and other animals, indicating that it is a promising method.
出处
《宜春学院学报》
2014年第6期5-11,114,共8页
Journal of Yichun University
基金
国家自然科学基金资助项目(项目编号:11105114)
关键词
分子间多量子相干
高分辨
核磁共振
不均匀磁场
生物组织
Intermolecular Multiple -quantum Coherences
Nuclear Magnetic Resonance （NMR）
High -resolution
Inhomogeneous Fields
Biological Tissue
