摘要
目的:探讨血清尿酸(SUA)水平与急性缺血性脑卒中(AIS)的关系。方法:采用病例对照研究的方法,纳入153例缺血性脑卒中患者为观察组,另选110例健康体检者为对照组,测定空腹血清尿酸值,采用NIHSS评估神经功能缺损程度,并分析血尿酸水平与缺血性脑卒中的关系。结果:(1)观察组中血尿酸水平、高尿酸血症患病率分别为(347.09±101.45)μmol/L、31.37%,与对照组比较差异有统计学意义(P<0.05)。(2)在急性缺血性脑卒中患者中,高尿酸者NIHSS评分高于正常尿酸者,差异有统计学意义(P<0.05);对153例患者的SUA与NIHSS进行Spearman秩相关分析显示,SUA与NIHSS评分呈正相关(r=0.206,P<0.01)。结论:急性缺血性脑卒中人群中血尿酸水平升高,高尿酸血症患病率高;血尿酸水平升高可能为急性缺血性脑卒中患者发病的危险因素。
Objective：To investigate the relationship between serum uric acid（SUA） levels and acute ischemic stroke（AIS）.Method：The case-control study was conducted to examine uric acid in 153 patients with ischemic stroke（observation group） and 110 outpatients（control group）.National Institutes of Health Stroke Scale（NIHSS） score was evaluated stroke severity.Spearman rank correlation was used to analyze the relationship between SUA and AIS.Result：（1）Mean serum uric acid levels in observation group were （347.09±101.45）μmol/L,and 31.37%were hyperuricemia（HUA）,they were significantly higher than those in control group（P〈0.05）.（2）In observation group,NIHSS score of HUA patients were higher than normal uricemia patients,and were proved statistically significant（P〈0.05）. Spearman rank correlation analysis showed that SUA was positive correlated with the NIHSS score in 153 patients with AIS（r=0.206,P〈0.01）.Conclusion：The high levels of SUA and prevalence of hyperuricemia were in patients with AIS.These findings suggest that elevated serum uric acid level can be considered as a risk factor for AIS.
出处
《中外医学研究》
2014年第18期21-22,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
缺血性脑卒中
血尿酸
Acute ischemic stroke
Uric acid
