摘要
利用放疗增敏剂提高肿瘤细胞对放射线的敏感性，改善放疗疗效，是现代肿瘤放疗学研究的方向之一。组蛋白去乙酰化酶抑制剂是一类表观遗传学修饰剂，可通过诱导细胞凋亡、抑制DNA双链断裂修复、阻滞细胞周期、改善乏氧状态和促进氧自由基产生等多种途径发挥放疗增敏作用。进一步研究基于分子机制的放疗增敏疗效预测标志物，将更利于临床个体化治疗。
One leading research target of modern tumor radiotherapy is to increase radiosensitization of tumor and improve curative effect of radiotherapy. Histone deacetylase inhihitors are epigenetie drugs that can play a part in radiosensitization through means of induction of apoptosis, inhibition of repair of DNA double- strand breaks, cell cycle arrest, improvement of tumor cell hypoxia and increase of reactive oxygen species. There is an urgent need to develop biomarkers based on these pathways, which can promote clinically individu- alized treatment.
出处
《国际肿瘤学杂志》
CAS
2014年第6期425-428,共4页
Journal of International Oncology
基金
国家自然科学基金（81272611）
