摘要
目的探讨卵巢无性细胞瘤的临床病理特征、诊断及鉴别诊断。方法回顾性分析7例卵巢无性细胞瘤的临床病理资料。结果7例患者最常见的腹部症状及体征为腹部包块(6例,85.71%),腹水(5例,71.43%),腹痛(2例,28.57%)。实验室检查LDH升高4例,NSE升高4例,β-HCG升高2例,CA125升高2例,AFP升高1例;7例均为手术切除标本,均行术中冰冻切片检查,镜下表现为瘤细胞为大小一致的圆形、多角形细胞组成,胞质丰富淡染,瘤细胞排列成条索状、巢状、岛屿状,其间均可见纤维组织间隔分隔,间隔内见多少不一淋巴细胞浸润。免疫组化示肿瘤细胞PLAP、CD117、OCT4、NSE呈不同程度阳性。结论卵巢无性细胞瘤是一种少见的恶性生殖细胞肿瘤,其临床表现无特异性,易误诊,需结合临床表现及实验室检查,确诊需依赖病理学检查及免疫组化。该病多见于年轻女性,尤其对于需保留生殖功能的女性,术中冰冻检查的形态学鉴别诊断尤为重要。
Objective To investigate the clinicopathologic features,diagnosis and differential diagnosis of ovarian dys-germinoma. Methods The clinicopathological data of 7 cases of ovarian dysgerminoma were retrospectively analyzed. Results The abdominal symptoms and signs included abdominal mass（n=6）, ascites（n=5） and abdominal pain（n=2）. The laboratory tests showed elevated serum lactate dehydrogenase（LDH）, neuronspecific enolase （NSE）, chorionic gonadotropin （β-HCG）, carbo-hydrate antigen 125 （CA125） and alpha fetoprotein （AFP） in 4,4, 2, 2 and 1 cases respectively. Al the cases underwent surgical excision of the ovary and frozen sections were made. Microscopical y,tumor cells were composed of uniform size circular, polyg-onal cells with rich and light- stain cytoplasm;tumor cells were ranged as cords,nests and islands and separated by fibrous belts which were thin and contained infiltrated lymphocytes. Immunohistochemistry showed different extent of positive stain of PLAP, CD117, OCT4 and NSE in tumor cells. Conclusion Ovarian dysgerminoma is a rare malignant germ celltumor with no specific clinical manifestations;the diagnosis depends on pathological examination and immunohistochemistry.
出处
《浙江医学》
CAS
2014年第12期1076-1078,共3页
Zhejiang Medical Journal
