摘要
慢性肾脏病（CKD）是全球重大公共健康问题之一。肾小球滤过率（GFR）是CKD早期诊断和正确分期的一个重要指标，如何准确便捷的估算GFR一直是临床工作的热点和难点。本文介绍了基于血清肌酐和胱抑素C建立GFR评估方程（eGFR）的发展历程，分析了研究方法对于方程评估效果的影响，并探讨了eGFR国内研究和应用中面临的问题。据此提出相应建议：（1）扩大研究规模（多个中心）和样本例数，建立和验证适用于国人的eGFR方程；（2）规范研究中的GFR“金标准”，统一分析评估法；（3）推进肌酐和胱抑素C检测结果一致化与标准化是方程广泛应用的基础。
Chronic kidney disease （CKD） is a worldwide public health problem. Glomerular filtration rate （ GFR ） is a key indicator for early diagnosis and accurate classification of CKD, how to estimate GFR accurately and conveniently has been a difficulty and hot-points. We describes the development of several major eGFR equations based on ereatinine and cystatin C, analysis the impact of the different research methods on performance of equation, and discusses the issue in research and application of eGFR in China. Accordingly make the following recommendations （1） Expand the study size （multiple centers） and participants number, then develop and validate eGFR equations based on Chinese population ; （2） Standardize the ＂gold standard＂ of GFR in the study and unify the analysis and evaluation methods; （ 3 ） Promote the consistency and standardization of ereatinine and eystatin C which is the basis for the wide range of applications of the eGFR formula.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2014年第6期406-409,共4页
Chinese Journal of Laboratory Medicine
关键词
肾功能不全
慢性
肾小球滤过率
肌酸酐
胱抑素C
参考标准
Renal insufficiency, chronic
Glomerular filtration rate
Creatinine
Cystatin C
Reference standards
