摘要
在大鼠心肌梗塞模型上，观察了α-受体阻断剂的抗心律失常作用。在对照组22只鼠中，由于心梗所致室早、室速 和室颤的出现率分别为77.3%、77.3%、59.1%，并有27.2%死亡，而用哌唑嗪鼾的大鼠（n=12)，只有41.6%出现早搏，未出现室速、室颤和死亡，酚妥拉明（n=12)和用利用血平耗竭儿茶酚胺（n=5)后，有类似结果，心得安（n=14)组与对照组无明显差别，哌唑嗪、酚妥拉明和心得安分别使心肌梗塞范围自475%减少到26.5%(P<0.01)、36.5%(P>0.05)和33.9%(P<0.05)，利血平耗竭儿茶酚胺后，梗塞范围最小，为18.6%(P<0.01)，心梗所致的心律失常，主要与α-受体有关，而α- 受体阻断剂与β-受体阻断剂均可减小梗塞范围。
Using the myocardial infarct model in rats, it was proved that α-receptor blocker had significant contribution to antiarrythmias. Among 22 rats in control group the incidence of ventricular extrasystole (VE), ventricular tachycardia (VT), and ventricular fibrillation (VF) induced by myocardial infarction was 77.3%, 77.3% and 59.1% respectively with a death rate of 27.2%, while among rats treated with prazosin (n=12) the incidence of VE was 41.6% with no VT VF and death. Similar was the result of phentolamine (n=12) and of depletion of catecholamines with reserpine (n=5). The effect of propranolol (n=14) was not significantly different from the control. The infarct size could be reduced by prazosin phentolamine and propranolol from 47.5% in control to 26.5% (P<0.01) 36.5% (P>0.05) and 33.9% (P<0.05). The smallest infarct size was found in rats depleted of catecholamines with reserpine. It is concluded that arrhythmias induced by myocardial infarction were related mainly to α-receptor, while both α-and β-receptor blockades could reduce the infarct size.
出处
《中国应用生理学杂志》
CAS
CSCD
1989年第3期283-288,共6页
Chinese Journal of Applied Physiology
