摘要
目的探讨CEA和CA199在胃癌诊断和临床病理分期中的临床应用。方法选取胃癌患者79例,根据有无手术治疗分为手术组(n=48)和未手术组(n=31),选取正常体检患者(对照组)50例和胃良性疾病作为参照,观察对照组、良性疾病组和胃癌组患者CA199和CEA水平及各项指标。结果对照组CA199和CEA水平最低,良性疾病组和胃癌组患者的CA199和CEA水平逐渐增高(P<0.01);手术前后CA199和CEA水平与手术前相比明显降低,有显著的统计学差异(P<0.01);而手术组患者的CA199和CEA水平随着分期的增加,CA199和CEA水平不断增加,有显著的统计学差异(P<0.01);手术组和未手术组胃癌患者术前年龄、CA199和CEA水平相比无明显的统计学差异(P>0.05)。结论 CEA和CA199水平可作为胃癌诊断、临床病理分期、疗效评价和预后评估的重要指标。
Objective To investigate the clinical application of CEA and CA199 in the diagnosis and clinical patho- logical staging of gastric cancer. Methods A total of 79 gastric cancer patients were divided into surgical group （n = 48） and non-surgical group （n = 31）. Subjects undergoing normal physical examination were as control group, and 50 patients with benign gastric disease were as reference group. CAl99 and CEA levels and other indexes were observed in these groups. Results CA199 and CEA levels were lowest in control group, and gradually increased in benign disease group and gastric cancer group （P〈0. 01）. CA199 and CEA levels were significantly lower after operation （P〈0. 01 ）. CA199 and CEA levels were increased with the increase of tumor-node-metastasis （TNM） grads （P〈0. 01）. No significant sta- tistical difference were observed between surgical and non-surgical groups with different ages, CA199 and CEA levels （P 〉0. 05）. Conclusion Blood CEA and CA199 levels can be used as important indicators in improving the diagnosis kate, judging the stages of clinical pathology, and evaluating curative effect and prognosis of gastric cancer.
出处
《华南国防医学杂志》
CAS
2014年第5期460-462,共3页
Military Medical Journal of South China
