摘要
目的观察丹红注射液治疗心血瘀阻型不稳定心绞痛(UA)的临床疗效。方法选择心血瘀阻型UA患者96例,按照数字表法随机分为治疗组和对照组各48例,对照组应用西药常规治疗(抗凝、调脂、扩血管等),治疗组在西药常规治疗基础上加用丹红注射液20 ml/d,2组均连续治疗14 d(1个疗程),于疗程开始前1d和结束后分别观察2组中医证候评分、心绞痛疼痛强度、发作次数及持续时间、静息心电图缺血改变、检测血液流变学及纤维蛋白原(Fg)水平等指标。结果 2组治疗后中医证候评分、心绞痛疗效、心电图变化、血液流变学及Fg水平较治疗前差异差异有统计学意义(P<0.05或<0.01)。结论丹红注射液治疗心血瘀阻型UA可改善患者中医临床症状、减少心绞痛发作次数及持续时间、降低心绞痛疼痛强度、明显改善心肌缺血,并能降低血液流变学及Fg水平,且无明显不良反应。
Objective To observe the clinical effect of Danhong injection on blood stasis type unstable angina（ UA）.Methods Ninety-six blood stasis type UA patients were randomly divided into the treatment group and the control group,each consisting of 48 patients. The patients in the control group were treated with routine western medicine（ anti-coagulation,lipid regulation,vasodilation drugs,etc）,while the patients in the treatment group were given routine western medicine plus Danhong injection,with a dosage of 20 ml /d and all were treated for 14 days（ a treatment course）. Traditional Chinese medicine syndrome scores,angina pain intensity,attack frequency and duration,and changes in resting ischemic electrocardiography,hemorheology and fibrinogen（ Fg） level for the two groups were detected,1 days before the treatment course began and shortly after termination of treatment. Results Following treatment,significant differences could be noted in traditional Chinese medicine syndrome cores,curative effect on angina pectoris,changes in ECG,blood rheological and Fg levels,as compared with those before treatment（ P〈0. 05 or P〈0. 01）. Conclusion Danhong injection in the treatment of blood stasis type UA could improve TCM clinical syndromes,reduce attack frequency and duration of angina pectoris,decrease angina pain intensity,improve obviously myocardial ischemia and reduce blood rheology and Fg levels. Furthermore,it did not produce obvious adverse reactions.
出处
《海军医学杂志》
2014年第3期188-190,共3页
Journal of Navy Medicine
基金
国家中医重点专项基金课题(1213096)
