摘要
药物性血管炎是由药物诱发的血管炎症,严重情况下会导致器官、组织损伤,甚至死亡。目前认为丙硫氧嘧啶是诱发血管炎的最常见药物,抗肿瘤坏死因子α药物、抗精神失常药物等也会诱发血管炎。药物性血管炎的发病机制尚不清楚,患者体内通常可检测出抗中性粒细胞胞浆抗体。及时确诊并尽快排查、停用诱发药物是治疗药物性血管炎的关键,并应根据症状严重程度进行个体化治疗。
Druginduced vasculitis is an inflammation of blood vessels caused by the use of various pharmaceutical agents. Vasculitis causes changes in the walls of blood vessels, including thickening, weakening, narrowing and scarring. Severe vasculitis can result in organ and tissue damage, even death. The most often implicated drug in the published work now is propylthiouracil, while antitumour necrosis factoralpha agents and psychoactive agents also can lead to vasculitis. The pathogenesis of drug-induced vaseulitis is unclear, but antineutrophil cytoplasmic antibodies are usually detected in drug-induced vasculitis patients. It is very important to make correct diagnosis and to stop the offending drugs immediately in the treatment of druginduced vasculitis, and individual therapy should be initiated according to the severity of organ involvement.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2014年第6期401-405,共5页
Chinese Journal of New Drugs and Clinical Remedies
关键词
血管炎
药物毒性
抗体
抗中性粒细胞胞质
药物性血管炎
vasculitis
drug toxicity
antibodies, antineutrophil cytoplasmic
drug-induced vasculitis
