摘要
目的探讨高分辨率食管测压（HRM）下胃食管反流病（GERD）患者吞咽延迟时间（DL）与食管动力的关系。方法51例行HRM且24h食管pH监测诊断为GERD的患者根据HRM结果是否存在食管异常蠕动分成动力异常组（n=28）和阴性组（n=23），另选择14例非GERD者行HRM作为对照（对照组），统计分析各组HRM监测结果。结果动力异常组DL（7．27±1．44）S明显高于阴性组的（6．704±41）S和对照组的（5．86±0．96）2，差异均有统计学意义（P〈0．01），且阴性组也明显高于对照组（P〈0．01）；动力异常组的远端收缩积分（712．49±703．10）mmHg·s·cm明显低于阴性组的（1285．85±850．83）mmHg·s·cm和对照组的（1109．74±611．70）mmHg·s·cm，差异均有统计学意义（P〈0．01），而阴性组与对照组比较差异无统计学意义（P〉0．05）；各组间食管下括约肌压力、收缩前沿速度及食管下括约肌处食团内部压力差异均无统计学意义（P〉0．05）。结论HRM下DL的延长与GERD患者食管蠕动减弱明显相关，GERD患者表现为更长的DL，证明食管动力的改变是GERD发生发展的重要环节。
Objective To investigate the relationship between esophageal motility and distal latency （DL） in gastroesophageal reflux disease （GERD） using high resolution manometry （HRM）. Methods A total of 51 GERD patients underwent HRM and 24 h-esophageal pH monitoring. According to the HRM to- pography （characterized as either break peristalsis or normal esophageal movement） , all GERD patients were divided into two groups ： hypomotility group（ n = 28 ） and normal group（ n = 23 ）. Fourteen non-GERD con- trols were enrolled. The monitoring results were analyzed. Results The HRM DL of 28 esophageal hypomotility patients（54. 9%, 28/51 ）were the longest（7.27± 1.44）s. Patients with normal peristalsis also had longer latency （6. 70± 1.41 ） s than the non-GERD controls （5.86 ± 0. 96 ） s. All the differences were statisti- cally significant（P 〈0. 01 ）. DCI of hypotensive peristalsis patients（712.49 ± 703.10）mmHg · s· cm was lower compared with the other groups [ （ 1 285.85 ±850. 83 ） mmHg · s· cm, （ 1 109. 74± 611.70） mmHg · s· cm] （P 〈 0. 01 ）. Other indicators such as LES pressure, CFV and IBP showed no significant differences among groups （ P 〉 0. 05 ）. Conclusion Esophageal manometry of GERD patients indicates that esophageal hypomotility is accompanied with prolonged DL. Because DL of all GERD sufferers are extended, esophageal dysmotility has great implications for GERD＇s development.
出处
《中华消化内镜杂志》
2014年第6期304-307,共4页
Chinese Journal of Digestive Endoscopy
关键词
胃食管反流病
高分辨率食管测压
吞咽延迟时间
食管动力
Gastroesophageal reflux disease
High resolution manometry
Distal latency
Esophageal motility
