摘要
病例1:患者,男性,46岁,因肝功能异常服用茵栀黄颗粒降酶退黄治疗,后出现呕吐、乏力,小便颜色进行性加深,并伴有畏寒、发热,体温最高达39.0℃。自行停药后体温降至正常,症状缓解。2个月后再次服用茵栀黄颗粒,畏寒、发热、乏力、尿黄症状再次出现。于外院查肝功能示:TBIL 65.7μmol·L-1,DBIL 34.8μmol·L-1,ALT 939.2 IU·L-1,AST 489.9 IU·L-1,γ-GT785.0 IU·L-1,诊断为药物性肝炎。即刻停药,予保肝、利胆、降酶治疗,45 d后,患者肝功能恢复正常。病例2:患者,女性,51岁,因急性戊型肝炎在我院住院治疗,治疗2个月病情好转后出院,出院后服用茵栀黄颗粒降酶退黄治疗10余天,服药期间出现发热、呕吐、腹胀、纳差,肝功能示:TBIL 22.8μmol·L-1,DBIL 16.0μmol·L-1,ALT 308.0 IU·L-1,AST 309.0 IU·L-1,γ-GT 237.0IU·L-1,AKP 258.0 IU·L-1,诊断为药物性肝炎。即刻停药,予保肝、退黄、降酶等对症治疗,35 d后,患者肝功能恢复正常。
Case 1 ： one 46-year-old male patient developed vomiting, lack of power, yellow urine with chill and fever after receiving Yinzhihuang granules for the treatment of abnormal liver function. The highest body temperature was 39.0 ℃. All the above symptoms alleviated after discontinuation of the drug. Two months later, Yinzhihuang granules were taken again and the symptoms of chill, fever, lack of power and yellow urine reappeared. Laboratory examinations were as follows： TBIL 65.7 μmol·L-1, DBIL 34.8 μmol·L-1, ALT 939.2 IU·L-1, AST 489.9 IU·L-1, γ-GT 785.0 IU·L-1. Drug-induced hepatitis was diagnosed and Yinzhihuang granules were stopped. Treatments of protecting liver function, depressing transaminase and abating jaundice were given to the patient. After 45 days, the patient discharged with normal liver function. Case 2： one 51-year-old female patient was admitted to hospital because of acute hepatitis E. The liver fimction of the patient recovered after 2-month treatment, and then the patient discharged with Yinzhihuang granules. Ten days later, the patient developed fever, vomiting, abdominal distention and anorexia. Laboratory findings were： TBIL 22.8 μmol·L-1, DBIL 16.0 μmol·L-1, ALT 308.0 IU·L-1, AST 309.0 IU·L-1, γ-GT 237.0 IU·Ll, AKP 258.0 IU·Ll. The patient was hospitalized again and the clinical diagnosis was drug-induced hepatitis. Yinzhihuang granules were stopped, and the symptomatic treatments of protecting liver function, depressing transaminase and abating jaundice were given immediately. About 35 days later, hepatic function of the patient recovered to normal.
出处
《中国药物应用与监测》
CAS
2014年第3期191-193,共3页
Chinese Journal of Drug Application and Monitoring
关键词
茵栀黄颗粒
药物性肝炎
肝损害
药品不良反应
YInzhihuang granules
Drug-induced hepatitis
Liver impairment
Adverse drug reaction
