摘要
目的 利用事件相关电位（Event-related potentials,ERPs）技术探讨高血压患者视觉注意功能障碍的特点及其神经机制.方法 采用视觉Oddball范式,分析15例原发性高血压患者和15例正常对照者的ERPs成分,并采用简易智能精神状态检查量表（MMSE）进行认知功能测评.结果 ①新异刺激：高血压患者N2波幅[（1.56±1.15）μV]较正常对照者[（-2.19±1.15）μV]显著减小（P＜0.05）,其中以额-中央下降更明显（P＜0.05）;高血压组[（6.27±1.01）μV]较正常对照组[（7.09±1.01） μV] P3a波幅降低,但差异无统计学意义（P＞0.05）;高血压组P3a潜伏期[（432.83±8.22） ms]较正常对照组[（403.10±8.22） ms]明显延长,差异有统计学意义（P＜0.05）;②靶刺激：高血压组视觉P3b波幅[（4.08±0.90）μV]较正常对照组[（6.75±0.90）μV]显著降低（P＜0.05）,且在顶区最明显（P=0.01）;高血压组[（440.70±6.42） ms]较正常对照组[（436.91±6.42）ms]的视觉P300的潜伏期延长,但差异无统计学意义（P＞0.05）;③与正常对照组（27.31±1.22）相比,高血压患者的MMSE评分（24.55±2.42）明显减小（P＜0.05）.视觉P3b的波幅与MMSE评分存在显著正相关（r=0.51,P＜0.05）.结论 高血压患者的非随意注意及随意注意能力均受到损害,且高血压病对两种注意影响的程度及神经机制不同.视觉P3b能为临床更早的评估高血压患者的注意功能提供更加客观的神经生理学依据.
Objective To investigate the characteristics and neural mechanisms of visual attention dysfunction in patients with hypertension using the event related potentials（ERPs）.Methods Visual Oddball pattern was adopted to analyze P3a and P3b components of 15 essential hypertensives and 15 normotensives,and all the participants were submitted to cognitive assessment by Mini-Mental State Examination （MMSE）.Results ①Novelty stimulus：the mean amplitude of N2 in hypertensive patients （（1.56± 1.15） μV） was decreased than normal controls （（-2.19±1.15） μV,P〈0.05）,particularly at forehead-central sites （P〈0.05）.In addition,the amplitude of P3a of hypertensive patients （（6.27± 1.01） μV） was different from normal controls （（7.09± 1.01） μV）,but there was no statistical significance（P〉0.05）.The latency of visual P3a was significantly longer in patients with hypertension group （（432.83 ± 8.22） ms） than that in control group （（403.10 ± 8.22） ms,P〉 0.05）.②Target stimulus：compared with control group （（6.75 ±0.90）μV）,visual P3b amplitude in hypertension group （（4.08 ± 0.90） μV） was significantly declined （P〈 0.05）.Besides,the latency of visual P3b of hypertensive patients （（440.70 ± 6.42） ms） was different from normal controls （（436.91±6.42） ms）,but there was no statistical significance（P〉0.05）.③Compared with control group （27.31± 1.22）,the M MSE score of patients with hypertension （24.55±2.42） was decreased （P〈0.05）.The amplitude of visual P3b was positively correlated with MMSE scores in parietal region（r=0.51,P〈0.05）.Conclusions The abilities of visual involuntary attention and voluntary attention are damaged in patients with hypertension,the impact degree of hypertension on two kinds of attention and the neural mechanisms are different.Moreover,there is a significant positive correlation between the amplitude of visual P3b and MMSE,which prompts that visual P3b for clinic
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2014年第6期500-503,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
山东省科学发展计划（2008GG30002058）
关键词
高血压
视觉
注意障碍
事件相关电位
Hypertension
Visual
Attention dysfunction
Event-related potentials
