摘要
目的观察综合心理干预对肺癌患者术后疼痛和血清白介素6（IL-6）及白介素10（IL-10）的影响。方法选取Ⅰ～Ⅱ期肺癌手术患者86例为研究对象,随机分为综合心理干预组51例,对照组35例,采用视觉模拟评分（visual analog scale,VAS）对疼痛进行评估,用酶联免疫吸附法（ELISA）测定血清IL-6及IL-10水平,观察并比较两组患者VAS评分及血清IL-6和IL-10的变化。结果与对照组比较,干预组在麻醉前及术后6 h、12 h、24 h和48 h的VAS评分均显著降低（P〈0.05）;与麻醉前比较,对照组于术后6 h、12 h、24 h和48 h血清IL-6水平均显著升高（P〈0.05）,而IL-10水平于术后12 h、24 h和48 h显著降低（P〈0.05）;干预组在麻醉前及术后6 h、12 h、24 h和48 h血清IL-6水平均较对照组显著降低（P〈0.05）,而血清IL-10水平均较对照组显著升高（P〈0.05）。结论综合心理干预能有效地缓解肺癌患者术后疼痛症状,促进恢复促/抑炎细胞因子平衡,缓解术后免疫损伤。
Objective To observe the influence of comprehensive psychological intervention on pain and serum IL-6 and IL-10 levels of patients after lung cancer surgery. Methods Eighty-six lung cancer patients were divided into two groups： 51 patients of the intervention group received psychological intervention, and 35 patients of the control group received routine nursing care. The pain of patients was measured by the visual analog scale （VAS）. The serum IL-6 and IL-10 levels were measured by ELISA. The indexes were compared between the two groups. Results VAS score of intervention groups were significantly lower than those in control group at preanesthesia and 6h, 12h,24h and 48h after operation （P 〈 0.05 ）. The serum IL-6 levels of control group at 6h,12h,24h and 48h after operation were significantly higher than those at preanesthesia. The serum IL-10 levels of control group at 12h, 24h and 48h after operation were significantly lower than those at preanesthesia. The IL-6 levels of intervention groups were significantly lower than those in control group at every point （ P 〈 0. 05 ）. The IL-10 levels of intervention groups were significantly higher than those in control group at every point （ P 〈 0.05 ）. Conclusion Comprehensive psychological intervention can effectively relieve pain of patients after lung cancer surgery. It could promote and recuperate the balance of cytokines and relieve the immunologic injury after operation.
出处
《微创医学》
2014年第4期444-447,共4页
Journal of Minimally Invasive Medicine
基金
广西卫生厅科研资助项目(编号:Z2012723)
