摘要
采用简便快捷的无种子法一步完成了纳米金棒的制备.通过改变实验条件可以调控纳米金棒的吸收峰从可见到近红外转移.将巯基聚乙二醇(PEG-SH)置换金棒表面的十六烷基三甲基溴化铵(CTAB)分子,大大提高了金棒的生物相容性.制备的纳米金棒在近红外(NIR)光照射下对肿瘤细胞有很好的杀伤效果.研究结果为纳米金棒用于抗肿瘤治疗提供了实验基础.
We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol （PEG-SH） was then used to substitute cetyltrimethyl ammonium bromide （CTAB） to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cellgrowth was observed with the modified gold nanorods under near-infrared （NIR） light irradiation. Our results wil be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy.
出处
《物理化学学报》
SCIE
CAS
CSCD
北大核心
2014年第7期1363-1369,共7页
Acta Physico-Chimica Sinica
基金
国家自然科学基金(21261130090
21073047)
中国科学院先导科技专项(XDA09030303)资助项目~~
关键词
纳米金棒
等离子共振吸收
生物相容性
表面修饰
热疗
Gold nanorod
Plasmon resonance absorption
Biocompatibility
Surface functionalization
Hyperthermia
