摘要
目的:了解我院药品不良反应发生的基本情况,为临床安全、合理用药提供参考。方法:回顾性分析我院2012-2013年收集到的211例ADR报告,并进行统计、分析。结果:211例ADR报告中,男性95例,女性116例,男、女比例为0.82∶1;年龄段以≥60岁患者发生率最高,达44.55%;民族以汉族ADR发生率最高,占82.94%;抗菌药物引发的ADR居首位(40.28%),其中β-内酰胺类引起的ADR最多,其次是喹诺酮类;临床表现主要以皮肤及其附件损害居多,有104例(49.29%)。严重的ADR有6例,占2.84%。结论:ADR的发生有多种因素。临床应重视和加强ADR的监测工作,尤其应加强对抗菌药物及中药注射剂的监测,促进合理用药。
OBJECTIVE： To analyze the general information of ADR in our hospital, and to provide reference for safe and rational drug use in the clinic. METHODS： In retrospective study, 211 cases of ADR reports in our hospital during 2012-2013 was analyzed statistically. RESULTS： Among 211 ADR cases, there were 95 male cases and 116 female cases, with male to female ratio of 0.82：1; the incidence of ADR was the highest in patients aged 60 years old or above, up to 44.55 %. The incidence of ADR was the highest in Han nationality, accounting for 82.94%. ADR caused by antibiotics took up the first place （40.28%）, among which most was induced by β-lactam-inducing ADR, followed by quinolone class; clinical manifestations were mainly lesion of skin and its appendants （104 cases, 49.29% ）. There were 6 cases of serious ADR, accounting for 2.84%. CONCLUSIONS： The occurrence of ADR is caused by various factors, and antibiotics and TCM injection monitoring should be strengthened. Great importance should be attached to ADR monitoring to promote the rational drug use.
出处
《中国药房》
CAS
CSCD
2014年第26期2454-2456,共3页
China Pharmacy
